Cepharanthine cancer
WebApr 13, 2024 · Cancer is a disease characterized by uncontrolled cell division and fast metastasis to various body parts. Cancer is the leading global threat affecting a large population. ... Cepharanthine inhibitory effect on TNF-α and phorbol 12- myristate-13-acetate (PMA)-induced HIV-1 replication in chronic infected monolytic and T-lymphocytic … WebJul 22, 2024 · Cepharanthine (CEP) is a naturally occurring alkaloid derived from Stephania cepharantha Hayata and demonstrated to have unique anti-inflammatory, antioxidative, immunomodulating, antiparasitic, and antiviral properties. Its therapeutic potential as an antiviral agent has never been more important than in combating COVID-19 caused by …
Cepharanthine cancer
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WebSep 1, 2024 · Cepharanthine (CEP) is a drug used in Japan since the 1950s to treat a number of acute and chronic diseases, including treatment of leukopenia, snake … WebNov 7, 2024 · An overexpression plasmid or siRNA against MYO1C were sequentially introduced into human breast cancer MDA-MB-231 cells. Results: We show here that cepharanthine (CEP), a novel autophagy inhibitor, inhibited autophagy/mitophagy through blockage of autophagosome-lysosome fusion in human breast cancer cells. …
WebBackground: Cepharanthine (CEP) is a biscoclaurine alkaloid extracted from Stephania cepharantha and has been shown to have an anti-tumour effect on different types of cancers. However, the anti-cancer effect of CEP on human breast cancer cells is still unclear. Methods: We used MTT, clone formation, in vitro scratch, invasion and … WebJun 15, 2024 · Alkaloids are known to be effective in the treatment of various diseases such as neurological disorders, cancer, metabolic disorders, and infectious diseases. ... So, cepharanthine could be a ...
WebOct 22, 2024 · Cepharanthine (CEP) is a natural plant alkaloid, and has anti-inflammatory, antineoplastic, antioxidative and anticancer properties. In this study, we investigated … WebNov 1, 2024 · Interestingly, the cancer cells exhibited a lower initial expression of both channels. With the increased number of targets for cepharanthine in PC-12, the cells remained more sensitive towards incubation with CEP. The results correlated with the higher cytotoxic effect on the normal cells in comparison to cancer. 5. Conclusions
WebNov 30, 2024 · In clinical research, Cepharanthine has been shown to exhibit multiple pharmacological properties including anti-oxidative, anti-inflammatory, immuno-regulatory, anti-cancer, anti-viral and anti-parasitic effects 5,6. However, historically cepharanthine's low oral bioavailability has represented a major obstacle to realizing its full clinical ...
WebJul 22, 2024 · Cepharanthine, a benzylisoquinoline alkaloid extracted from Stephania cepharantha Hayata, is a natural anti-inflammatory and antineoplastic agent approved for clinically use to treat a variety of... redaction modeWebJun 26, 2024 · 6 State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. PMID: 31293986 PMCID: PMC6606789 DOI: ... The natural product, Cepharanthine hydrochloride (CEH), is known for its anticancer and immunoregulatory properties. By … know in present perfect tenseWebDec 4, 2024 · 1 INTRODUCTION. Cancer is one of the most common causes of death, with liver cancer ranking fourth among malignant tumors, making it a serious hazard to human health. 1 According to global trends, more than one million people are expected to be affected by hepatocellular carcinoma (HCC) per year by 2025. 2 Developing countries … redaction microsoftWebCorrection to: Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine. ... 被引量: 0. 收藏 相关文章. 99mTc Radiolabeled HA/TPGS-Based Curcumin-Loaded Nanoparticle for Breast Cancer Synergistic Theranostics: Design, in vitro and in vivo Evaluation. 2024 ... redaction momaWebCepharanthine, a biscoclaurine alkaloid isolated from the roots of Stephania cephalantha Hayata, has been reported to demonstrate antitumor activity across multiple cancer types; however, the mechanisms are still under investigation. High transcriptional responses by both the Hedgehog and Wnt pathways are frequently associated with specific human … redaction moliereWebCepharanthine (CEP), a medicinal product derived from Stephania cephalantha Hayata, possesses a potent cytotoxicity against several types of cancers. Recently, we have found that CEP could efficiently inhibit the growth of mutated p53 colon cancer cells, which are often resistant to commonly used chemotherapeutic agents. redaction noticeWebOct 15, 2024 · Cepharanthine reproducibly demonstrates potential as a monotherapy in treating multiple cancers with unsatisfactory treatment optionsIdentified 4 cancer types … redaction mowgli