Dimethylnitrosamine demethylase
WebTwo enzymic forms, with different kinetic characteristics and responding in opposite ways to in vivo “enzyme inducer” pretreatment, underlie hepatic dimethylnitrosamine(DMN)-demethylase activity. Determination of the Hofstee plot of DMN-demethylase using a DMN substrate concentration range of 0.5 to 200 mM yields three intersecting line segments … WebDimethylnitrosamine (DMN) is a semi-volatile organic chemical that is a probable human carcinogen. The close family members of N-nitrosamines commonly present in the …
Dimethylnitrosamine demethylase
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Webwas reported that dimethylnitrosamine (DMN) might be one of the causative agents that induce liver damage ... (PB) that increase hepatic demethylase activity.19 However, this assumption was somewhat challenged in a later report in which it was shown that the specific alkylation density of the cellular WebOct 1, 1970 · Summary. Previous studies on the inhibitory action of pretreatment of rats with 3-methylcholanthrene (MC) and other polycyclic hydrocarbons on the hepatic …
WebDOI: 10.1016/0009-2797(76)90002-8 Corpus ID: 28426319; Dimethylnitrosamine-demethylase: absence of increased enzyme catabolism and multiplicity of effector sites in repression. WebAlthough the DMN demethylase activity of hamster liver S-9 was contained in the microsomal fraction, DMN mutagenesis under conditions of the assay required the presence of both microsomal and cytosolic (S-105) fractions; the cytosols from hamsters, mice, and rats were all effective.
WebTwo enzymic forms, with different kinetic characteristics and responding in opposite ways to in vivo “enzyme inducer” pretreatment, underlie hepatic dimethylnitrosamine(DMN) … WebJan 1, 2024 · The relationship between dimethylnitrosamine (DMN) demethylase activity and DMN-induced mutagenesis was investigated in Drosophila melanogaster. The …
WebFeb 1, 1977 · It has been observed that some forms of NDMA demethylase have relatively low values for K m (< 5 mM) whereas others have higher values (> 35 mM), and in liver …
WebDMN demethylase activity may be the primary controlling factor in the metabolism ofDMN to a mutagen, and probably to a carcinogen; other simultaneous pathways of DMN metabolism proportional to demethylation have not been ruled out. 75 The mutagenicity of nitrosopyrrolidine is related to its metabolism. L. I. Hecker, R. Elespuru, J. Farrelly au データお預かり アドレス帳 削除WebThe effects of 3-methylcholanthrene (3MC) and dimethylnitrosamine (DMN), administered singly or in combination at chronic carcinogenic doses, on the evolution of activity patterns of enzymes involved in the metabolism of DMN and polycyclic hydrocarbons were studied in the liver and lung of Sprague-Dawley rats and Swiss mice. au データmaxプランproWebNov 1, 1979 · Benzylamine, a typical inhibitor of mitochondrial monoamine oxidase (MAO), is a potent inhibitor of DMN-demethylase activity, but microsomes are devoid of MAO … 加わるWebSemantic Scholar extracted view of "Dimethylnitrosamine-demethylase: absence of increased enzyme catabolism and multiplicity of effector sites in repression. Hemoprotein … 加世田梨花 インスタWebThe N-nitrosamides are unstable at physiological pH and decompose non-enzymatically to a reactive intermediate capable of reacting with cellular macromolecules. The N-nitrosamines are, however, stable at … au データお預かり pc ログインWebAbstract. The nature of enzymes involved in demethylation of N-nitrosodimethylamine (NDMA) was investigated in hepatic microsomes of rats. Compared to the other … 加世田 アメリカ村 営業時間WebA dimethylnitrosamine (DMN) demethylase with levels of activity comparable to that in uninduced rat liver was demonstrated in both larval and adult forms of the Hikone-R … 加世田市ボタンボウフウ