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Dual specificity protein kinase clk2

WebSep 23, 2024 · Human CLK2 has received increasing attention as a regulator that phosphorylates serine- and arginine-rich (SR) proteins and subsequently modulates the alternative splicing of precursor mRNA (pre-mRNA), which is an attractive target for degenerative disease and cancer. WebPurpose: To explore the role of CDC-like kinase 2 (CLK2) in the development and progression of lung cancer and its regulatory mechanism. Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assay was used to detect the expressions of micro ribonucleic acid (miR)-573 and CLK2 in non-small cell lung cancer …

Pharos : Target Details - CLK2

http://sea.docking.org/jobs/search_e77e8e0a-6977-42c8-9fc8-da56098e0b20 WebPTHR45646:SF6 DUAL SPECIFICITY PROTEIN KINASE CLK2 1 hit; PTHR45646 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED 1 hit; PROSITE. View protein in PROSITE; PS00107 PROTEIN_KINASE_ATP 1 hit; PS50011 PROTEIN_KINASE_DOM 1 hit; PS00108 PROTEIN_KINASE_ST 1 hit; Pfam. View protein in Pfam; PF00069 … de havilland swallow https://urbanhiphotels.com

Human Gene CLK2 (ENST00000368361.9) from GENCODE V43

WebFeb 5, 2024 · Go to Variation Viewer for CLK2 variants; Summary. This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. WebCLK2_HUMAN: CLK2: Dual specificity protein kinase CLK2: 4.81e-06: 0.43: ST17A_HUMAN: STK17A: Serine/threonine-protein kinase 17A: 5.343e-06: 0.43: KPCD3_HUMAN: PRKD3: Serine/threonine-protein kinase D3: 6.63e-06: 0.43: DYRK4_HUMAN: DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase … WebCDC-like kinase 2 nucleus, protein serine/threonine kinase activity, nucleotide binding, ATP binding, protein phosphorylation, protein binding, nucleolus, response to retinoic … de havilland sea vixen top speed

CDC2-like (CLK) protein kinase inhibition as a novel targeted

Category:CLK2 CDC like kinase 2 - NIH Genetic Testing Registry (GTR) - NCBI

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Dual specificity protein kinase clk2

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http://sea.docking.org/jobs/search_45e16e26-30e2-4c82-9df3-28f475ef4832 WebThe cdc2-like kinases (CLKs) are an evolutionarily conserved group of dual specificity kinases belonging to the CMGC (cyclin-dependent kinases (CDKs), mitogen-activated …

Dual specificity protein kinase clk2

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WebQuery Target Key Target Name Description P-Value MaxTC; compound_1 . PARP1_RAT: Parp1: Poly [ADP-ribose] polymerase 1: 5.09e-154 WebDual specificity mitogen-activated protein kinase kinase 2: 1.337e-07: 0.32: CLK4_HUMAN: CLK4: Dual specificity protein kinase CLK4: 1.553e-07: 0.39: E3UJZ5_SPOLI: Ecdysone receptor: 1.59e-07: 0.29: CCNE1_HUMAN: CCNE1: G1/S-specific cyclin-E1: 1.68e-07: 0.45: DCLK1_HUMAN: DCLK1: Serine/threonine-protein …

WebApr 7, 2024 · The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12 ...

WebCDC-like kinase 2 nucleus, protein serine/threonine kinase activity, nucleotide binding, ATP binding, protein phosphorylation, protein binding, nucleolus, response to retinoic acid, nuclear speck, protein tyrosine kinase activity, response to ionizing radiation, negative regulation of gluconeogenesis, peptidyl-tyrosine phosphorylation, protein … WebCC-671 is a potent and selective inhibitor of both TTK (human protein kinase monopolar spindle 1 [hMps1]) and CDC like kinase 2 (CLK2). It represents a new class of cancer …

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WebJun 30, 2010 · Structure of human CDC2-like kinase 2 (CLK2) de havilland support limitedWebThe dual specificity kinase MEK1 controls Golgi disassembly by activating several regulatory kinases ( Fig. 23.1). MEK1 is a central player of the MAP kinase signal … de havilland sea vixen cockpitWebJun 15, 1998 · The prototype, murine Clk1 (mClk1), is a nuclear dual-specificity kinase that can interact with, and cause the nuclear redistribution of, SR proteins. In this study, … de havilland sea venom aircraftWebThis gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the … fendal softwareWebDec 15, 1999 · Abstract. CLK3, a member of the LAMMER family of dual-specificity protein kinases, is abundantly expressed in the reproductive system of male mice. Specifically, high levels of CLK3 protein expression are found in mature spermatozoa in the testis and epididymis. The majority of the CLK3 protein in the testis is a full-length … fend amazon buildWebDescription: Homo sapiens CDC like kinase 2 (CLK2), transcript variant 3, mRNA. (from RefSeq NM_001294339) RefSeq Summary (NM_001294338): This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of … fendall single eye wash station 32 ozhttp://sea.docking.org/jobs/search_dd920cdf-bc2e-44c7-9fbd-8f637cdbcca7 de havilland t shirt