WebSep 23, 2024 · Human CLK2 has received increasing attention as a regulator that phosphorylates serine- and arginine-rich (SR) proteins and subsequently modulates the alternative splicing of precursor mRNA (pre-mRNA), which is an attractive target for degenerative disease and cancer. WebPurpose: To explore the role of CDC-like kinase 2 (CLK2) in the development and progression of lung cancer and its regulatory mechanism. Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assay was used to detect the expressions of micro ribonucleic acid (miR)-573 and CLK2 in non-small cell lung cancer …
Pharos : Target Details - CLK2
http://sea.docking.org/jobs/search_e77e8e0a-6977-42c8-9fc8-da56098e0b20 WebPTHR45646:SF6 DUAL SPECIFICITY PROTEIN KINASE CLK2 1 hit; PTHR45646 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED 1 hit; PROSITE. View protein in PROSITE; PS00107 PROTEIN_KINASE_ATP 1 hit; PS50011 PROTEIN_KINASE_DOM 1 hit; PS00108 PROTEIN_KINASE_ST 1 hit; Pfam. View protein in Pfam; PF00069 … de havilland swallow
Human Gene CLK2 (ENST00000368361.9) from GENCODE V43
WebFeb 5, 2024 · Go to Variation Viewer for CLK2 variants; Summary. This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. WebCLK2_HUMAN: CLK2: Dual specificity protein kinase CLK2: 4.81e-06: 0.43: ST17A_HUMAN: STK17A: Serine/threonine-protein kinase 17A: 5.343e-06: 0.43: KPCD3_HUMAN: PRKD3: Serine/threonine-protein kinase D3: 6.63e-06: 0.43: DYRK4_HUMAN: DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase … WebCDC-like kinase 2 nucleus, protein serine/threonine kinase activity, nucleotide binding, ATP binding, protein phosphorylation, protein binding, nucleolus, response to retinoic … de havilland sea vixen top speed