The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as … See more The cytoplasmic domains of the EpoR contain a number of phosphotyrosines that are phosphorylated by Jak2 and serve as docking sites for a variety of intracellular pathway activators and Stats (such as Stat5). … See more Mice with truncated EpoR are viable, which suggests Jak2 activity is sufficient to support basal erythropoiesis by activating the necessary pathways without phosphotyrosine … See more Erythropoietin receptor has been shown to interact with: • CRKL, • Erythropoietin, See more • Erythropoietin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine See more Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Overproduction of red blood cells increases a chance of adverse cardiovascular … See more • Zhu Y, D'Andrea AD (Mar 1994). "The molecular physiology of erythropoietin and the erythropoietin receptor". Current Opinion in … See more WebErythropoietin (EPO), a cytokine hormone, is responsible for the regulation of red blood cell (erythrocyte) production. EPO is a glycoprotein produced by cells of the peritubular …
novel mutation in the erythropoietin receptor gene is associated …
WebThe process of erythropoiesis in the fetal liver and adult bone marrow is regulated by the hormone erythropoietin (Epo), which is produced in the kidney at low levels under … WebNov 19, 2024 · Jones et al. (1990) isolated the human homolog of the murine erythropoietin (EPO; 133170) receptor (EPOR) from an erythroleukemia cell line and … switching blood pressure meds
New agents that stimulate erythropoiesis Blood American …
WebThe erythropoietin receptor has been cloned by an expression strategy from a cDNA library of murine erythroleukemic cells (D‘Andrea et al., 1989). The human erythropoietin receptor gene is localized on chromosome 19p (Winkelman et al., 1990). There are eight exons and seven introns, encoding a 507 amino acid peptide with a molecular weight of ... WebApr 15, 2002 · The molecular basis for the observed phenotype of isolated erythrocytosis is heterozygosity for a novel nonsense mutation affecting codon 399 in exon 8 of the erythropoietin receptor (EPOR) gene, encoding an EpoR peptide that is truncated by 110 amino acids at its C-terminus. WebThe major clinical benefits of ESAs are effective treatment of anemia and avoidance of blood transfusion risks. Erythropoietin (EPO) interacts directly with the EPO receptor on the … switching bodies