Guanyl-nucleotide exchange factor activity
WebGuanyl-nucleotide exchange factor activity Definition: Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. ID: GO:0005085 WebGuanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. Synonyms. GDP …
Guanyl-nucleotide exchange factor activity
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WebPredicted to enable guanyl-nucleotide exchange factor activity. Involved in spermatid development. Predicted to be located in cytoplasm and nuclear body. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B3. Orthologous to human SBF1 (SET binding factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6 ... WebMay 6, 2024 · The isolated DH domain of Tuba showed concentration-dependent guanyl nucleotide exchange activity with Cdc42 , but not with Rho (ARHA; 165390) or Rac . Otani et al. (2006) showed that Tuba concentrated at the apical-most region of cell junctions in a human colon carcinoma cell line via its interaction with ZO1 (TJP1; 601009). RNA …
WebGuanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. ... guanyl-nucleotide exchange factor activity Source:SGD. 2 publications. Biological Process ... WebMar 21, 2024 · ARHGEF38 (Rho Guanine Nucleotide Exchange Factor 38) is a Protein Coding gene. Diseases associated with ARHGEF38 include Bardet-Biedl Syndrome 6 . Among its related pathways are p75 NTR receptor-mediated signalling and GPCR downstream signalling .
WebPredicted to enable guanyl-nucleotide exchange factor activity; phosphorylation-dependent protein binding activity; and phosphotyrosine residue binding activity. Involved in immune response-regulating cell surface receptor signaling pathway. Predicted to be located in cell-cell junction. Predicted to be active in cytoplasm. WebMar 29, 2024 · 29-Mar-2024 Summary Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to be located in early endosome; late endosome; and midbody. [provided by Alliance of Genome Resources, Apr 2024] Other designations
WebDescription: Mus musculus RAS, guanyl releasing protein 2 (Rasgrp2), transcript variant 1, mRNA. (from RefSeq NM_011242) Gencode Transcript: ENSMUST00000167240.7 Gencode Gene: ENSMUSG00000032946.16 Transcript (Including UTRs)
WebTDR Targets ID: 578688 Echinococcus granulosus, cytohesin 1 Source Database / ID: GeneDB pI: 8.4469 Length (AA): 449 MW (Da): 50086 Paralog Number: 0 my horse is a vixenWebDescription: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably … ohio state buckeye football radio networkWebStimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is … ohio state buckeye football 2022 scheduleWebBinding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). ohio state buckeye footballWebJul 31, 2014 · One prevalent mechanism involves aberrant Rho activation via the deregulated expression and/or activity of Rho family guanine nucleotide exchange … ohio state buckeye football helmet logoWebFurthermore, functional analyses showed that SGK2 related genes were associated with protein serine/threonine kinase activity, guanosine triphosphatase (GTPase) activity, guanyl-nucleotide exchange factor activity, and motor activity. my horse is my best friendWebFunctions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. ohio state buckeye football schedule 2020