Hepatokine
WebMay 20, 2024 · Importantly, our data provide evidence that sFNDC4 acts as a hepatokine, as we observed that lowering of liver FNDC4 mRNA led to corresponding lowering of the sFNDC4-circulating levels in mice. WebJun 2, 2015 · Novel discoveries in hepatokine research may lead to promising biomarkers and treatments for metabolic disorders and type 2 diabetes. This is one of a series of commentaries under the banner ‘50 years forward’, giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965–2015).
Hepatokine
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WebJun 1, 2024 · Remodelling of hepatokine secretion is an adaptation to regular exercise training that induces changes in metabolism in the liver and skeletal muscle. SDC4 is a novel exercise-responsive hepatokine that decreases fatty acid uptake and reduces steatosis in the liver. By understanding the proteomic changes in hepatocytes with … WebNational Center for Biotechnology Information
WebMay 25, 2016 · Aims/hypothesis Type 2 diabetes is highly correlated with nonalcoholic fatty liver disease (NAFLD). Hepatocyte-derived fibrinogen-related protein 1 (HFREP1) is a hepatokine that mediates NAFLD development; however, the role of HFREP1 in the development of insulin resistance and diabetes remains obscure. Methods A total of 193 … WebJul 14, 2024 · A recent study identified MANF as a hepatokine induced by feeding and revealed its potential role in energy homeostasis and obesity . Circulating MANF levels …
WebMay 27, 2024 · Here, we aimed to clarify the clinical impact of the hepatokine selenoprotein P in patients with HF. Methods and Results. This is a prospective observational study that enrolled 296 participants consisting of 253 hospitalized patients with HF and 43 control subjects. First, we investigated selenoprotein P levels and found that its levels were ... Hepatokines (Greek heapto-, liver; and -kinos, movement) are proteins produced by liver cells (hepatocytes) that are secreted into the circulation and function as hormones across the organism. Research is mostly focused on hepatokines that play a role in the regulation of metabolic diseases such as diabetes and fatty liver and include: Adropin, ANGPTL4, Fetuin-A, Fetuin-B, FGF-21, Hepassocin, LECT2, RBP4,Selenoprotein P, Sex hormone-binding globulin.
WebHepatokines are liver-secreted proteins that regulate whole-body metabolism. Montgomery et al. identified sparc-related modular calcium-binding protein 1 (SMOC1) as a glucose …
WebJul 7, 2014 · FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases. Fibroblast growth factor (FGF) family members are mostly secreted as signaling proteins with diverse functions in development and metabolism. FGF21 is a unique FGF with metabolic, but not proliferative activities. diamond credit union loan ratesWebJan 22, 2013 · The first hepatokine that has been proven to have a major pathogenetic role in metabolic diseases is α2-HS-glycoprotein (fetuin-A). Production of this glycoprotein is … circuit city bangor maineWebIn conclusion, the hepatokine FGF-21 seems to play a role in the physiology of lipid metabolism, which renders it an appealing candidate for the treatment of some patients with NASH. There are favoring experimental and clinical results in phase 2 clinical trials. These have led to Phase 3 clinical trials, whose results may clarify whether FGF ... circuit city at fairfield oh 90sWeb1 day ago · This hepatokine is secreted by the liver and acts locally, in peripheral tissues and in the brain to regulate food preference and energy expenditure (discussed further later) 87,88,89. circuit city bayshoreWebApr 6, 2024 · First, this is a cross-sectional study, so causal relationships could not be established, and the sample size is relatively small; we conducted a detailed statistical analysis by adjusting multiple potential confounding factors to overcome. Second, CT-1 is not only recognized as an adipokine but also serves as a hepatokine . Since it was … circuit city backWebFeb 22, 2024 · The findings of this study indicate ERAP1 is an inflammation-induced hepatokine that impairs SM insulin sensitivity. Its inhibition may provide a therapeutic … circuit city bermudaWebOct 18, 2024 · A role for the hepatokine selenoprotein P in exercise adaption. The systemic level of a hepatokine may alter the response to exercise even if it is not regulated by physical activity. The plasma concentration of the hepatokine selenoprotein P (SeP) has been linked to the training responsiveness in VO 2 max in humans and mice. circuit city ballroom