Hydrophilic vs lipophilic statins
Web13 nov. 2024 · It has been hypothesized that the lipophilic statin drugs are more likely to reach and readily enter extrahepatic cells, whereas hydrophilic statins are more hepatoselective ( 56 ). WebOverlap propensity score-weighted logistic regression analyses were assessed to determine associations of the prior use of statins (any statin, hydrophilic statins vs. lipophilic statins) with incident gastric cancer and its mortality depending on the medication duration (<180 days, 180–545 days, and >545 days) after adjusting for multiple covariates.
Hydrophilic vs lipophilic statins
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WebLipophilic statins were superior to hydrophilic rosuvastatin regarding all-cause mortality (OR 0 · 50; 95 % CI, 0 · 11-0 · 89; p = 0 · 01), cardiovascular mortality (OR 0 · 61; 0 · 25 … Web23 apr. 2013 · It appears lipophilic statins produce better survival and other outcome benefits compared to hydrophilic statins. But the two types have not been compared in direct comparison trials in HF. Methods/design. We will conduct a systematic review and meta-analysis of lipophilic and hydrophilic statin therapy in patients with HF. Our …
Web30 jul. 2024 · Lipophilic statins penetrate muscle more easily than hydrophilic statins and are associated with a higher incidence of adverse effects, particularly myopathy, … Web28 aug. 2007 · Lipophilic statins cross the blood-brain barrier more readily, which may lead to central nervous system complaints such as insomnia, although this is rare.Hydrophilic statins exhibit greater ...
WebNational Center for Biotechnology Information Web22 jun. 2024 · Investigators also highlighted no significant differences were observed for any of the outcomes of interest based on use of hydrophilic or lipophilic statins. Further analysis suggested baseline neurocognitive function was an effect modifier for the associations of statins with dementia ( P for interaction <.001) and memory change ( P …
Web11 apr. 2024 · Subgroup analyses stratified by pharmacokinetic properties of statins (hydrophilic vs lipophilic), as previous studies, showed inconsistent results regarding the protective effect of hydrophilic ...
Web9 jun. 2024 · Hydrophilic statins are liver specific, whereas lipophilic statins are widely distributed in different tissues. Objective: to examine whether hydrophilic or lipophilic statins are associated with a lower risk of incident heart failure (HF). bakerzin menuWeb28 mrt. 2024 · The incidence rate of OCSCC was significantly lower in statin users compared to nonusers (17.12 vs. 26.75 per 10 000 person-years), yielding an incidence rate ratio of 0.64. ... The risk of OCSCC was lower among users of both hydrophilic and lipophilic statins. Conclusion. bake saleWeb4 apr. 2024 · Hydrophilic vs. Lipophilic Statins in Diabetic Patients ― Comparison of Long-Term Outcomes After Acute Myocardial Infarction ― April 2024 DOI: 10.1253/circrep.CR-20-0020 bake sale clipartWeb22 jan. 2024 · Lipophilic statins are widely distributed in different tissues, whereas hydrophilic statins are liver specific . Lipophilic statins include atorvastatin, simvastatin, … arburesa 2000Web1 jun. 2024 · The independent between-group ANOVA yielded a statistically significant effect, F (2, 59) = 6.69, p < 0.05, ⴄ2 = 0.21 in the spine. Thus, patients on lipophilic statins had statistically lower BMD than females on hydrophilic statins. The visual depiction of the means and 95% confidence intervals is presented in Fig. 3. bake sale recipes sandra leeWeb3 mrt. 2024 · In general, lipophilic drugs tend to penetrate into the body to a much greater extent. Of highest importance is penetration into the CNS (brain). CNS side effects are possible with statins but are not common in … bakerzin singaporeWeb13 nov. 2024 · It has been hypothesized that the lipophilic statin drugs are more likely to reach and readily enter extrahepatic cells, whereas hydrophilic statins are more … arburg 470 c datasheet