Myc phosphorylation sites
Web25 dec. 2024 · Pak2 is a serine/threonine kinase that participates in the cellular response to stress. Among the potential substrates for Pak2 is the protein Myc, encoded by the proto … Web1 jan. 1994 · c-Myc is a nuclear phosphoprotein which binds DNA as a heterodimer with Max. We have identified two in vivo phosphorylation sites, Thr58 and Ser62, within a …
Myc phosphorylation sites
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WebPhosphoSitePlus ® is an online systems biology resource for information and tools related to the study of post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation, and methylation. Created with grant support from the NIH and … WebThis initial phosphorylation stabilizes c-Myc. GSK3β activates and phosphorylates c-Myc at a secondary site. The initial site is then dephosphorylated by protein phosphatase 2A …
WebThe time window of phosphorylation and dephosphoryla- tion at these two sites is affected by Pin1-mediated cis-trans isomerization of the Ser62-Pro motif, thereby regulating … WebPhosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential. The nuclear proto-oncoprotein c-Myc is involved in the regulation of cell growth …
Web29 aug. 2024 · MYC hyperphosphorylation can be rescued specifically with exogenous PP1, but not other phosphatases. Hyperphosphorylated MYC retained interaction with its …
Web13 nov. 2024 · In this study, we unravel a non-mitotic role of AURKB in promoting MYC stabilization via direct MYC phosphorylation at an unconventional site. Our findings …
Web14 apr. 2024 · Abstract. The mammalian target of rapamycin (mTOR) pathway is frequently involved in the pathogenesis of human tumorigenesis. mTOR forms two protein complexes: mTORC1 which responds to growth and stress factors resulting in the phosphorylation of 4EBP1 and S6K for their deactivation and activation, respectively; and mTORC2 which … christ redeemer lutheran church brecksvilleWebMyc also represses transcription at alter-native DNA sites through association with other transcriptional activators such as Miz-1. The first 143 residues contain se-quences … gfr is measured inWeb7 aug. 2024 · Research has identified two interdependent phosphorylation sites that are critical for the regulation of MYC stability and function. While these sites are conserved across MYC family members, we focus here on c-MYC (‘MYC’, unless otherwise specified). gfr is 15 what does that meanWeb16 jun. 2011 · MYC is a master transcription factor (recent estimates suggest that it might regulate upto 15% of the genes) governing many critical cell functions such as metabolism, proliferation and survival. 13 It is also a very potent oncogene, which might be involved in up to 70% of cancers. 14-16 However, MYC is also a particularly complex factor, which, … gf-rj45-r-32 mencomWeb13 jul. 2024 · A. In normal cells, RAS signaling leads to MYC phosphorylation at S62, which supports PIN1 isomerization of P63 to cis, recruitment of MYC to target gene … christ redeemer catholic church huffmeisterWebIn lung adenocarcinoma induced by c-myc, the expression of hexokinase-2 in mitochondrial was up-regulated near 5-fold and contributed significantly to the apoptosis inhibition. 31 In Burkitt’s lymphoma, it was reported by Kim et al that dysregulated c-myc collaborated with HIF-1α to induce hexokinase-2 overexpression and resulted in the metabolic switches to … christ redeemer lutheran church trumbull ctWeb31 okt. 2013 · There are four described phosphorylation sites in the N-terminus of MYC including T58, S62, S71, and S81. Two additional clusters of residues have also been … gfr is 55 what does that mean