WebA selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. A calcium sensing receptor agonist used to treat secondary hyperparathyroidism in chronic kidney disease and hypercalcemia ... Webparoxetine perphenazine propafenone propoxyphene quinacrine quinidine ritonavir sertaline terbinafine thioridazine: None: amitriptyline carvedilol chlorpromazine clomipramine …
Paroxetine: MedlinePlus Drug Information
WebCYP2D6. Cytochrome P450 2D6 ( CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra . CYP2D6, a member of the cytochrome P450 mixed-function oxidase system, is one of the most important ... WebDec 30, 2015 · Pharmacodynamics. Paroxetine treats the symptoms of depression, various anxiety disorders, posttraumatic stress disorder, obsessive-compulsive disorder, and the vasomotor symptoms of menopause via the inhibition of serotonin reuptake. 26,29,30 The onset of action of paroxetine is reported to be approximately 6 weeks. 18 Due its … gambitstacey
The Effect of Cytochrome P450 Metabolism on Drug Response
WebOn discussion with a colleague, the emergency department physician learned that both paroxetine and fluoxetine can inhibit cytochrome P450 enzymes (isoforms) responsible … WebParoxetine metabolism is carried out by cytochrome P450 (CYP) 2D6. Paroxetine can saturate CYP2D6 resulting in a nonlinear relationship between dose and serum concentration. Paroxetine clearance is significantly affected by reduced hepatic function but only slightly by reduced kidney function. A typical adult paroxetine dose is 20 mg per day. WebJul 26, 2024 · The cytochrome P450 enzyme genes were CYP2C19 for citalopram; CYP2D6 for paroxetine; CYP2D6 and CYP2C9 for fluoxetine, and CYP2C19 and CYP2D6 sertraline . Genotypes, including both rare and common variants, were translated into diplotypes using star allele nomenclature, when applicable, as described in PharmVar ( … gambit solutions inc