Pten-induced putative kinase 1
WebDOI: 10.1016/j.jbc.2024.104691 Abstract Mitophagy is a cargo-specific autophagic process that recycles damaged mitochondria to promote mitochondrial turnover. PTEN-induced putative kinase 1 (PINK1) mediates the canonical mitophagic pathway. WebOur data revealed that miR-593-5p inhibits a signaling pathway involving PTEN-induced putative kinase 1 (PINK1) and Parkin, two proteins responsible for the removal of …
Pten-induced putative kinase 1
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WebJan 26, 2024 · Mutations in the gene for the serine/threonine protein kinase PTEN-induced putative kinase 1(PINK1) are the second most frequent cause of autosomal recessive Parkinson's disease (PD). Via its kinase activity, PINK1 regulates neuronal cell survival and mitochondrial quality control. WebDissection of the function of two Parkinson's disease-linked genes encoding the protein kinase, PTEN-induced kinase 1 (PINK1) and ubiquitin E3 ligase, Parkin, has illuminated a …
WebMay 14, 2024 · The serine/threonine kinase phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) controls mitochondrial quality and plays a vital role in the pathogenesis of early-onset Parkinson's disease. However, whether PINK1 has functions in innate antiviral immunity is largely unknown. WebMay 5, 2016 · A mitochondrial kinase, PTEN-induced putative kinase 1 (PINK1), selectively recruits the ubiquitin ligase Parkin to damaged mitochondria, which modifies mitochondria by polyubiquitination, leading to mitochondrial autophagy.
WebFeb 23, 2024 · Ref (2)P is a crucial downstream effector of a pathway involving Pink1 and Parkin. Notch interacts with PTEN-induced kinase 1 (PINK1) to influence mitochondrial … WebProtein Kinases PTEN-induced putative kinase Proteasome Endopeptidase Complex GTP Phosphohydrolases MFN2 protein, human Grant support R01 HL071115/HL/NHLBI NIH HHS/United States R01 HL113003/HL/NHLBI NIH HHS/United States RC1 HL099462/HL/NHLBI NIH HHS/United States CIHR/Canada
WebJun 29, 2024 · Kidney stone disease is a lifestyle-related disease prevalent in developed countries; however, effective medical treatment for the disease is not yet well established. As cellular damage in renal tubular cells (RTCs) is responsible for the disease, here, we focused on the role of macroautophagy/autophagy in RTCs.
WebMutations in the PTEN induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). So far, no substrates of PINK1 have been … osteria da albertoWebDec 13, 2024 · PMID 36414008, PTEN-induced kinase 1 enhances the reparative effects of bone marrow mesenchymal stromal cells on mice with renal ischaemia/reperfusion … osteria corte perettiWebFeb 23, 2024 · Is expressed in organism. Used to study Hirschsprung's disease; Parkinson's disease (multiple); and testicular cancer. Human ortholog (s) of this gene implicated in … osteria costa at mgm national harborWebMar 9, 2024 · PTEN-induced putative kinase 1 (PINK1) is a well-characterized regulator of mitochondrial quality control through mitophagy and its mutations are associated with … イヴァン4世 父WebAfter stimulation of bpv (phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy was inhibited, while apoptosis and releases of Cytochrome C were both significantly increased, indicating an exacerbated H/R injury. osteria da carmine riesebyWebFeb 1, 2024 · Dissection of the function of two Parkinson's disease-linked genes encoding the protein kinase, PTEN-induced kinase 1 (PINK1) and ubiquitin E3 ligase, Parkin, has … イヴァン アレク 兄弟WebApr 8, 2024 · Parkin-induced protein kinase 1 (PINK1) is a sensor of mitochondrial health, and activation of PINK1 regulates one of the most well-defined mitophagy pathways 5,6. However, the role of PINK1 as a tumor suppressive surveillance mechanism for enhancing survival and proliferation are context dependent 7, 8, 9. osteria da bacco monza