Rhizopodin
TīmeklisSymmetry helps: The total synthesis of the potent actin-targeting C 2-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late-stage introduction of the labile side chains. TīmeklisSymmetry helps: The total synthesis of the potent actin-targeting C 2-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late-stage introduction of the labile side chains.
Rhizopodin
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TīmeklisConfigurational Assignment of Rhizopodin, an Actin-Binding Macrolide from the Myxobacterium Myxococcus stipitatus Nicole Horstmann‡ and Dirk Menche*,†,‡ † University of Heidelberg, Department of Organic Chemistry, INF 270, D-69120 Heidelberg, Germany and ‡ Helmholtz Centre for Infection Research (HZI), Medicinal … Tīmeklis2012. gada 13. febr. · Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining. The field of bacterial natural …
TīmeklisThe relative and absolute stereochemistry of the 38-membered myxobacterial polyketide rhizopodin, a potent actin-binding macrolide, was determined by J-based configurational analysis in combination with molecular modeling and … Tīmeklis2024. gada 2. febr. · The ‘GiSelA 5’ rootstock is of high importance for growing sweet cherries because it significantly reduces the growth vigour of the trees and accelerates their fruiting. However, the method of its propagation using ‘in vitro’ cultures is expensive, prompting researchers to look for alternative …
TīmeklisRhodopsin, also known as visual purple, is a protein encoded by the RHO gene and a G-protein-coupled receptor (GPCR). It is the opsin of the rod cells in the retina and a light-sensitive receptor protein that … TīmeklisRhizopodin shows potent antifungal and antiproliferative cytotoxicity against a range of tumor cell lines with IC50 values in the low nanomolar range and has also been shown to reduce phagocytosis efficiency of yeast cells. Rhizopodin (1, Scheme 1) is an architecturally unique polyketide macrolide that was originally isolated from the …
Tīmeklis2024. gada 29. dec. · Fraser’s photinia ‘Red Robin’ (Photinia x fraseri Dress, Rosaceae family) is an important primary ornamental landscaping species with optimal hedge or screen effects and low maintenance, but it is difficult to root when propagated by cuttings, although high …
Tīmeklis2012. gada 4. jūn. · Rhizopodin ( 1 , Scheme 1 ) is an architecturally unique polyketide macrolide that was originally isolated from the myxobacterium Myxococcus stipitatus by the groups of Höfle and Reichenbach. 1 , 2 It shows potent antifungal and antiproliferative cytotoxicity against a range of tumor cell lines with IC 50 values in … hunter house admission criteriaTīmeklisThe C1–C15 fragment of rhizopodin was synthesized through either Suzuki coupling reaction of vinyl iodide and vinyl boronate or cross-metathesis of a terminal olefin and a diene adduct in the presence of Hoveyda–Grubbs II catalyst. Key words cross-metathesis - cross-coupling - stereocontrolled synthesis - conjugated diene - … hunter house cafe ingram texasTīmeklisAbstract. The relative and absolute stereochemistry of the 38-membered myxobacterial polyketide rhizopodin, a potent actin-binding macrolide, was determined by J -based … hunter house and gardens