Web31 Mar 2015 · SND1 is an AEG-1/MTDH/LYRIC-binding protein that is upregulated in numerous human cancers, where it has been assigned multiple functional roles. In this study, we report its association with the TGFβ1 signaling pathway, which promotes epithelial–mesenchymal transition (EMT) in breast cancer. Web14 May 2014 · A01, a high affinity Smurf1 inhibitor (Cao et al., 2014; Kaiser et al., 2024), was purchased from Merck (#SML1404). Ten-d-old diapause-destined pupae were injected with different concentrations of ...
Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by
Web12 Feb 2024 · SMURF1 increases ER alpha stability, possibly by inhibiting K48-specific poly-ubiquitination process on ER alpha protein. Interestingly, SMURF1 expression could be induced via estradiol treatment. ... In order to confirm the role of SMURF1 in ER alpha signaling, we utilized one selective SMURF1 inhibitor –A01 to treat breast cancer cell … Web21 Sep 2024 · The membrane was blocked with 5% bovine serum albumin (BSA) at room temperature for 2 h to block nonspecific binding and incubated at 4 °C overnight with … severndroog castle london
Inhibition of osteoblastic Smurf1 promotes bone formation
Web13 Apr 2024 · In addition, reduction of Kindlin-2 by Smurf1 was blocked by treatment with MG132, an inhibitor of the proteasome , suggesting that the effect of Smurf1 on Kindlin-2 degradation is mediated by the proteasomal protein degradation pathway. Furthermore ... Smurf1 mediates Kindlin-2 proteasomal degradation. (A) GFP-Kindlin-2 plasmid (2 µg) … Web27 May 2010 · To determine whether forced expression of Smurf1 induces JunB protein degradation, we cotransfected Myc-tagged Smurf1 (M-Smurf1) and Flag-tagged JunB (F … Web17 Nov 2024 · Although SMURF1 and SMURF2 both play an important role in the TGF-β signaling pathways to regulate tumor biology, SMURF1 often promotes tumor growth, … severndroog castle wedding