WebMar 7, 2024 · SPHK inhibitors reduce the generation of venetoclax resistance induced by activated T cells. The results mentioned above prompted us to evaluate whether SPHK inhibitors affect the generation of venetoclax resistance. To this aim, we employed the dual SPHK1/2 inhibitor SKI-II and the SPHK2 inhibitor opaganib. WebSep 4, 2015 · Recent studies have characterized a novel SphK2 inhibitor, ABC294640, which was shown to suppress growth of breast, kidney, and pancreatic cancer cells [18–20]. ABC294640 is a non-lipid competitive inhibitor of SphK2, and exhibited chemotherapeutic pharmacological efficacy in animal models without systemic toxicity [18–20]. However, …
METTL3-mediated m6A methylation of SPHK2 promotes gastric …
WebNov 4, 2024 · Administration of the selective SphK2 inhibitor ABC294640 profoundly suppresses the growth of HepG2 or SK-HEP-1 HCC xenografts [ 26 ]. Knockdown or inhibition of SphK2 sensitizes HCC cells to... WebIn human, SphK2 is known to promote apoptosis, suppresses cell growth, and controls cell migration; in addition, the specific ablation of SphK2 activity was reported to inhibit … streetcar new orleans tickets
Frontiers Therapeutic Potential of SphK1 Inhibitors Based on …
WebMar 20, 2024 · To this aim we employed the dual SPHK1/2 inhibitor SKI-II and opaganib, a SPHK2 inhibitor that is being studied in clinical trials. We found that SPHK inhibitors reduce the activation of CLL cells and the generation of venetoclax resistance induced by activated T cells mainly due to a reduced upregulation of BCL-XL. We also found that SPHK2 ... WebNov 10, 2024 · Knockout of TRIM22 using Cas9-sgRNAs resulted in decreased mRNA level of SPHK2 in GBM cells, while overexpression of TRIM22 enhanced it. The ERK1/2 driven luciferase reporter construct identified TRIM22 as a potential activator of MAPK signaling. WebABC294640 is a novel selective inhibitor of SphK2 that has been found to exert broad anticancer activity. The application of ABC294640 enhanced the effects of specific antitumor drugs, such as TRAIL-induced apoptosis in NSCLC cells ( 20) and paclitaxel-induced apoptosis in Caov-3 ovarian cancer cells ( 37 ). streetcar scene 5 analysis