Thioredoxin domain-containing protein 5
WebJan 18, 2024 · T hiosulfate Sulfurtransferase like Domain Containing 1 Protein Interacts with Thioredoxin Marouane Libiad 1 ǂ , Nicole Motl 1 ǂ , David L. Akey 2 , Naoya Sakamoto 4 , Eric R. Fearon 3 , Janet L ... Thioredoxin domain-containing protein 5 (TXNDC5) is a member of the protein disulfide isomerase (PDI) family. It can promote the formation and rearrangement of disulfide bonds, ensuring proper protein folding. TXNDC5 has three Trx-like domains, which can act independently to introduce disulfide bonds rapidly … See more TXNDC5 is a member of the PDI family. PDI consists of four Trx-like domains (a, b, bʹ, aʹ) and a C-terminal domain (c) (Fig. 1a). The a and aʹ domains have redox activity due to the CxxC motif, and it can also catalyse the … See more Similar to most members of the PDI family, TXNDC5 can catalyse the formation and rearrangement of disulfide bonds, thereby … See more TXNDC5 can promote cancer development in many ways, and they are summarized in Table 2. Like other PDI family members, TXNDC5 can participate in the formation of disulfide bonds, promoting the correct folding of proteins in … See more Currently, TXNDC5 is considered as a cancer-enhancing gene [24, 25]. It can protect cancer cells from oxidative stress and promote cancer growth, proliferation, migration and … See more
Thioredoxin domain-containing protein 5
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WebThioredoxins are a class of small (12-kDa) multifunctional regulatory proteins occurring in all types of cells.1–4 Plants contain three types of thioredoxin—two in chloroplasts ( f and … WebApr 28, 2014 · Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein family that lacks activity with classical Trx1 substrates.
WebTwo novel proteins, mimecan and thioredoxin domain–containing protein 5 (TXNDC5), were further validated by Western blot in 8 colorectal adenomas and 19 cancers that were matched with normal mucosa. All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01). WebDec 1, 2024 · As a critical member of the PDI family, thioredoxin domain containing protein 5 (TXNDC5) assists the folding of newly synthesized peptides to their mature form …
WebSep 28, 2024 · DOI: 10.1016/j.gendis.2024.09.003 Corpus ID: 57012805; A critical role of the thioredoxin domain containing protein 5 (TXNDC5) in redox homeostasis and cancer development @article{Chawsheen2024ACR, title={A critical role of the thioredoxin domain containing protein 5 (TXNDC5) in redox homeostasis and cancer development}, … WebJul 8, 2024 · Interestingly, although several thioredoxin domain-containing proteins were present in the oxidoreductase enzyme cluster, two primary members of this class, thioredoxin reductase 1 and 2 were ...
WebApr 4, 2024 · In the studies presented here, we identified thioredoxin domain containing 5 (TXNDC5), a cardiac fibroblast (CF)-enriched endoplasmic reticulum (ER) protein, as a novel mediator of cardiac fibrosis. TXNDC5 is upregulated in failing human and mouse hearts and TXNDC5 and fibrogenic protein expression levels are strongly correlated.
WebMay 31, 2024 · Through MS analysis, we determined that Srx forms a complex with the ER-resident protein thioredoxin domain–containing protein 5 (TXNDC5). Using reciprocal co-immunoprecipitation, immunofluorescence imaging, subcellular fractionation, and domain-mapping assays with site-specific mutagenesis and purified recombinant proteins, we … cost of postage stamp for 2023WebPossesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The … breakthrough device designation criteriaWebThe redox regulator sulfiredoxin forms a complex with thioredoxin domain-containing 5 protein in response to ER stress in lung cancer cells Hedy A Chawsheen 1# ; Hong Jiang 1 ; Qi Ying 1 , Na Ding ... cost of postage new zealandWebTwo novel proteins, mimecan and thioredoxin domain–containing protein 5 (TXNDC5), were further validated by Western blot in 8 colorectal adenomas and 19 cancers that were … breakthrough device designation reimbursementWebJun 1, 2001 · Thioredoxin domain-containing protein 17 Alternative names 14 kDa thioredoxin-related protein ( TRP14) Protein 42-9-9 Thioredoxin-like protein 5 Gene … breakthrough device designation definitionWebAbstract. Thioredoxin (Trx) is an inflammation-inducible small oxidoreductase protein ubiquitously expressed in all organisms. Trx acts both intracellularly and extracellularly … breakthrough device designation bddWebMar 29, 2024 · thioredoxin domain containing 15 provided by HGNC Primary source HGNC:HGNC:20652 MIM:617778; AllianceGenome:HGNC:20652 Gene type protein coding … cost of postage stamp 2020