WebNov 30, 2024 · Thioredoxin interacting protein (Txnip) is an α-arrestin protein that regulates pleiotropic biological responses. Txnip acts as a cancer suppressor and is a critical regulator of energy metabolism. To investigate molecular mechanisms involving Txnip, we searched for its protein binding partners using tandem affinity purification and proteomics ... WebAbstract. Thioredoxin (Trx) is an inflammation-inducible small oxidoreductase protein ubiquitously expressed in all organisms. Trx acts both intracellularly and extracellularly and is involved in a wide range of physiological cellular responses. Inside the cell, Trx alleviates oxidative stress by scavenging reactive oxygen species (ROS ...
7295 - Gene ResultTXN thioredoxin [ (human)] - National Center …
WebJan 23, 2007 · Loses its reducing activity, interaction with APEX1 and transcription activation; when associated with S-35. 1 publication. Sequence: C → S: ... PTHR46115:SF1 THIOREDOXIN-LIKE PROTEIN 1 1 hit; PIRSF. PIRSF000077 Thioredoxin 1 hit; PRINTS. PR00421 THIOREDOXIN; PROSITE. View protein in PROSITE; PS00194 THIOREDOXIN_1 1 … WebApr 1, 2008 · Recently, we identified thioredoxin-interacting protein (TXNIP) as a highly glucose-regulated proapoptotic factor in β-cells (), suggesting that it may represent a … fresh and raw
UniProt
WebThioredoxin protein has two cysteine residues in its active site that is a part of antioxidant system.. Thioredoxin system consists of Trx protein, thioredoxin reductase, NADPH coenzyme, and thioredoxin-interacting protein. • Trx system also plays a role in various biological functions such as regulation of apoptosis, redox regulation of transcription … Trx1 has been shown to downregulate cardiac hypertrophy, the thickening of the walls of the lower heart chambers, by interactions with several different targets. Trx1 upregulates the transcriptional activity of nuclear respiratory factors 1 and 2 (NRF1 and NRF2) and stimulates the expression of peroxisome … See more Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN … See more The primary function of Thioredoxin (Trx) is the reduction of oxidized cysteine residues and the cleavage of disulfide bonds. Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, … See more Thioredoxin has been shown to interact with: • ASK1, • Collagen, type I, alpha 1, See more • RuBisCO - enzyme activity regulated by thioredoxin • Peroxiredoxin - enzyme activity regulated by thioredoxin See more They are found in nearly all known organisms and are essential for life in mammals. See more Thioredoxin is a 12-kD oxidoreductase protein. Thioredoxin proteins also have a characteristic tertiary structure termed the thioredoxin fold. … See more Thioredoxin is used in skin care products as an antioxidant in conjunction with glutaredoxin and glutathione. See more WebMay 6, 2024 · We identified thioredoxin-binding protein-2 (TBP-2) as a protein that interacts with thioredoxin, which is an important regulator of the cellular oxidation/reduction (redox) system (36, 55, 146). The redox-regulating activity of thioredoxin-interacting protein (Txnip) is one aspect of its function ( 108 , 182 ). fresh and raw tour